Kapangidwe katsopano ka zinthu zopangira

Kudzipangira tokha kwa maselo

--mankhwala obiriwira a m'malire opanda kusweka ndi kulumikizidwanso

Mfundo yaikulu ya kudzipangira mamolekyulu:

1. Chikoka chonga - kuyendetsa zinthu zofanana kuti zisonkhane ndikukonzedwa, ndi zinthu zokhala ndi makhalidwe ogwirizana kuti zikoke wina ndi mnzake.

2. Mphamvu yotsika kwambiri—kuyenda kwa zinthu ndi machitidwe a mamolekyu zimakhala zokhazikika kwambiri. Ndi njira yoti magulu a mamolekyu azikonzedwa m'mapangidwe apamwamba.

Kapangidwe ka mamolekyulu pakati pa mamolekyulu kangathandize kwambiri ntchito ya zamoyo:

1. Molekyu iliyonse ili ndi kapangidwe kake kapadera komanso magwiridwe antchito ake, ndipo n'kovuta kukwaniritsa mgwirizano ndi chithandizo cholondola kutengera kusakaniza kwaulere pamlingo wopangira.

2. Palinso mamolekyu ambiri omwe ali ndi ntchito yabwino kwambiri ya zamoyo zomwe zachepetsa kwambiri kuyamwa ndi kugwiritsa ntchito kwawo chifukwa cha makhalidwe awo oipa.

3. Mankhwala achikhalidwe aku China ndi ofunika kwambiri kwa "mfumu, nduna ndi othandizira", osati kwa anthu ambiri, koma ndi abwino kwambiri.

Kusintha kwa kapangidwe ka Supramolecular ndi njira yowunikira bwino:

1. Kuwunika kwapamwamba kothandizidwa ndi kompyuta kuti muwone mwachangu zinthu zoyenera kuchokera ku Cambridge Crystal Data Center.

2. Gwiritsani ntchito chiphunzitso cha density functional kuti muphunzire kapangidwe ka supramolecular ndi makhalidwe a assembly omwe amatsimikiziridwa ndi mphamvu zapakati pa mamolekyulu, ndikupeza mtundu wa supramolecular womwe ndi njira yopangira.

3. Pofufuza momwe zinthu zilili komanso zovuta zake, kapangidwe ka supramolecular kanakonzedwa bwino.

4. Kuwerengera katundu wosiyanasiyana wa ma supramolecule, kuphatikizapo katundu wamagetsi, kuwala ndi thermodynamic.

5. Kuwerengera katundu wa ma spectral monga ma molecular spectrum ndi mphamvu spectrum.

6. Kudzera mu ukadaulo wa ma molecular docking, malo olumikizirana pakati pa zinthu zopangira supramolecular ndi mapuloteni ofunikira amaloseredwa, ndipo njira yolumikizirana pakati pa mamolekyu imafotokozedwa mozama.

Ukadaulo wa mchere wa Supramolecular eutectic/Ionic

Zinthu zaukadaulo: choyamba mumakampani, kufufuza zigawo zabwino kwambiri za CP za zigawo zogwira ntchito zolimbitsa eutectic

Ubwino: kuchepetsa kuyabwa, kuonjezera kusungunuka, kupititsa patsogolo magwiridwe antchito, kulimbikitsa kutseguka kwa madzi, kupititsa patsogolo kukhazikika

Zitsanzo za zosakaniza: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK

Zosakaniza zachilengedwe zomwe zatengedwa kuchokera ku kabukhu ka zinthu zopangira zodzikongoletsera, pambuyo pa mayeso otsimikizira monga kuyerekezera kwa quantum chemical, kuwunikira kwapamwamba, kukonza kwa Gaussian, KingDraw, MestReNova, FTIR, ndi NMR, zinthu zomwe zapezeka zili ndi kapangidwe kabwino kwambiri ka kristalo ka magawo atatu, kukhazikika bwino, kuyera kwambiri, kusayera kochepa. Zingathe kuthetsa bwino ululu wa zosakaniza zogwira ntchito mu chakudya, mankhwala ndi zodzoladzola, ndikuwonjezera kupezeka kwa bioavailability ndi chitetezo cha zosakaniza zogwira ntchito.

Ukadaulo wochotsa ntchito ya Supramolecular

zinthu zachilengedwe: Choyamba cha makampaniwa, kuphatikiza ukadaulo wosindikiza mamolekyulu ndi zosungunulira zachilengedwe za supramolecular, kutulutsa bwino zosakaniza zogwira ntchito m'minda

Ubwino: Kuchotsa molunjika, mphamvu yochotsa imawonjezeka ndi nthawi 5 poyerekeza ndi kuchotsa mowa, ndipo kuchotsa madzi kumawonjezeka ndi nthawi 20; palibe kulekanitsa, kuchepetsa ndalama, Zosakaniza zolimbikitsa kulowa kwa madzi Zitsanzo: olive (oleuropein, hydroxytyrosol), rhodiola, medical Phyloporus, white water lily, micrococcus

Chosungunulira chachilengedwe cha deep eutectic (NaDES): Chinapezeka koyamba ndi asayansi pofufuza metabolomics ya zomera. Pa nthawi zina za kukula kwa zomera (kumera, kusungidwa kwa madzi), maselo amapanga madzi okhuthala kwambiri osadalira madzi ndi mafuta, mofanana ndi chisakanizo cha eutectics.

Kutengera ukadaulo wamakono wolekanitsa zobiriwira, ukadaulo wophatikizika wa nembanemba, wowonjezeredwa ndi ukadaulo wowonjezera wa ultrasound / microwave kuti ukwaniritse kutentha kochepa, kolunjika, kwapamwamba, kwapamwamba komanso kobiriwira kwa zinthu zogwira ntchito. Kudzera mu solute yachilengedwe ya supramolecular monga solute yochotsera mphamvu, imathetsa mavuto ambiri monga kugwira ntchito kochepa, mtengo wokwera komanso kuvutika pakubwezeretsa madzi otayira kuchokera ku zotulutsa zachikhalidwe za phytochemical. Zosungunulira za supramolecular zochotsedwa zasankhidwa chifukwa cha magwiridwe antchito awo. Solute yosankhidwa ya supramolecular ili ndi magwiridwe antchito okhazikika komanso kusungunuka kwa zosakaniza zogwira ntchito, komanso mphamvu yochotsera imatha kuwonjezeka ndi nthawi 20.

Ukadaulo wolowera wa Supramolecular synergistic

Zinthu Zaukadaulo: Choyamba cha makampaniwa, kudzera mu supramolecular solvent, chimalimbikitsa kulowa kwa ma macromolecules/madzi osungunuka/zovuta kuyamwa zosakaniza.

Ubwino waukadaulo: kukhazikika bwino, kukulitsa kulowa kosawononga komanso kogwira mtima, mphamvu yogwirizana, kukulitsa njira mu dermis, komanso kupezeka kwa bioavailability kwawonjezeka ndi nthawi 5-7. Zitsanzo za zosakaniza: collagen, Bosein, blue copper peptide, hexapeptide, compound peptide, β-glucan.

Popeza kulemera kwa mamolekyu a peptide ndi kwakukulu poyerekeza ndi zosakaniza zina zogwira ntchito, kulowa kwa khungu kumakhala kochepa. Njira zina zowonjezera kulowa zimafunika kuti peptide ilowe bwino, kuti ikwaniritse kukhudzika kochepa komanso kugwira ntchito bwino, komanso kuti ikwaniritse bwino polimbana ndi ukalamba.

Poyankha vuto la kufalikira kwa zinthu m'makampani, kufalikira kwa madzi ambiri komanso kupezeka kochepa kwa ma macromolecule achikhalidwe, kupanga zinthu za JUNAS Time Particle kudzera mu quantum chemistry komwe kumathandizidwa, kumatha kufikira mwachindunji epidermis ndi dermis ya khungu kudzera mu trans-cellular, intercellular ndi follicular sweat ducts. Popanda kuwononga kapangidwe ka khungu. Kupezeka kwa zinthuzo kumawonjezeka ndi nthawi 5, kuphatikiza oposa 45% mu dermis, popanda kuwononga kapangidwe ka khungu. Kulowa kwa zinthuzo ndi nthawi yokhazikika kwachitika bwino kwambiri. Ichi ndi choyamba cha mtundu wake mumakampaniwa.

Ukadaulo wa Supramolecular biocatalysis

Katalysis yotsogozedwa ndi bioenzyme: zosungunulira za supramolecular zimagwiritsidwa ntchito ngati magawo kuti ziwonjezere ntchito ya enzyme, kukulitsa kusankha kwa chiral, komanso kukhala ndi chiyero chapamwamba

Kupanga fennel green fermentation: sankhani zomera zomwe zimadziwika bwino, onjezerani zomwe zili mu zosakaniza zogwira ntchito, fomula yopanda madzi, onjezerani mphamvu yonse

Ukadaulo wa micellar fermentation: kufufuza mitundu yodziwika bwino, kuwiritsa mafuta a masamba, zotsatira zambiri, kukonza kumverera kwa khungu ndikuwonjezera kuyamwa

Kutengera ukadaulo wa majini obwerezabwereza, ukadaulo wopangira majini okwana sitepe imodzi, ndi ukadaulo wopangira ma enzyme ochulukirapo, mabakiteriya opangidwa ndi majini amagwiritsidwa ntchito ngati zonyamulira zoyambitsa kuti apange zinthu zambiri zogwira ntchito:

Pansi pa dongosolo la supramolecular solvent, enzyme imawonetsa ntchito yapamwamba, kusankha bwino komanso kukhazikika, kugwiritsa ntchito kwambiri zinthu zopangira pansi, kuipitsa pang'ono pakupanga, mikhalidwe yofatsa yochitira zinthu, magwiridwe antchito apamwamba komanso magwiridwe antchito opangira.

Ukadaulo wa micelle fermentation wosinthika:

Mafuta achilengedwe osankhidwa okhala ndi makhalidwe aku China lP amapangidwa mwachibadwa kuti apange ma surfactants mothandizidwa ndi mabakiteriya opangidwa ndi majini.lt imasonkhanitsidwa ngati chonyamulira cha phukusi lotsutsana ndi micellar kuti lipange kukulunga kwa phukusi lotsutsana ndi micellar la zosakaniza zogwira ntchito zosungunuka m'madzi kuti zikwaniritse zochitika zambiri zogwiritsidwa ntchito, chidziwitso chabwino kwambiri pakhungu, komanso luso lodabwitsa, chidziwitso, komanso magwiridwe antchito ofunika.

Ukadaulo wa Supramolecular microencapsulation

Zinthu zaukadaulo: kutsekeka kwa liposome, kutulutsidwa kwa maselo a khungu, kutulutsidwa kwa tsitsi, komanso kutulutsidwa kwa zinthu zotupa.

Ubwino: Kutulutsa madzi pang'ono, kutumiza molondola, kutulutsa madzi nthawi yayitali, kuchepetsa kukwiya, kukonza kukhazikika, komanso kulimbikitsa kulowa kwa madzi m'thupi.

Zitsanzo za zosakaniza: astaxanthin, glabridin, vitamini A, blue copper peptide, biotin, ceramide, mafuta ofunikira a zomera

Ukadaulo wa Supramolecular microencapsulation umachokera ku liposome, emulsion yamafuta, ukadaulo wokhazikitsa madzi a ionic, ukadaulo wotulutsa maselo a khungu, ukadaulo wotulutsa tsitsi, komanso ukadaulo wotulutsa zinthu zotupa. Mwa kupanga njira zonyamulira zopangira, mankhwalawa amatha kupereka zosakaniza zogwira ntchito molondola. Ali ndi mphamvu yabwino kwambiri yoyamwa kwa transdermal, amakhala nthawi yayitali komanso amakhala okhazikika bwino pamalo omwe khungu likufunidwa. Alinso ndi ntchito zotsika mtengo komanso zothandiza kwambiri pankhani yodzola, zakudya zogwira ntchito komanso mankhwala.

Ukadaulo wodzipangira wekha wa Peptide

Zinthu zaukadaulo: njira yoyamba yoyendetsera kapangidwe ka ma amino acid ndi ma polypeptides m'makampani, ma peptides afupi odzisonkhanitsa okha, ma polypeptides a supramolecular

Malangizo aukadaulo: Kukweza kuchuluka kwa madzi m'mlengalenga, kulimbitsa bata ndi kukana kutentha, kuchepetsa poizoni ndi kupsinjika kwa chitetezo chamthupi, kulimbikitsa kuyamwa, ndi kugwirizana

Zitsanzo za zosakaniza: supramolecular carnosine, yisiti protein peptide

Kudzipangira mapuloteni ndi ma peptide sikuti kumangokhala paliponse m'machitidwe amoyo okha, komanso ndi chinthu chabwino kwambiri chachilengedwe cha thupi la munthu, komanso njira imodzi yothandiza yopangira zinthu za nano-biological. Njira yodzipangira peptide ndi njira yopangira ma peptide, ndipo "kapangidwe ka zipper ka polar amino acid" ndi mtundu watsopano wa kapangidwe ka super-secondary, komwe kumathandiza kuti ma peptide akhale ndi ma aggregates okonzedwa.

Kuwongolera kukula kwa ma peptide afupiafupi kungatheke mwa kusintha kusagwirizana kwa madzi ndi nthambi za m'mbali mwa zotsalira za hydrophobic.

Kutengera ndi database yapadera ya Shinehigh Innovation ya ProteinDataBank (PDB), kuphatikiza ndi kuyang'anira koyeserera, mphamvu zama molekyulu ndi mawerengedwe a quantum chemistry kuti mufufuze kapangidwe ka mamolekyulu a peptide, kenako kuwagwirizanitsa ndi mamolekyulu odzipangira okha omwe ali ndi mphamvu zambiri. Kusintha mtundu, chiwerengero ndi malo a amino acid pakati pa mamolekyulu a peptide kuti asinthe kapangidwe kake kopindika, motero kukulitsa luso la molekyulu kudzipangira lokha. Dziwani momwe ma peptide amagwirira ntchito. Peptide yodzipangira yokha ili ndi amphiphilicity yabwino kwambiri komanso yofanana, zomwe zimathandizira kwambiri kukhazikika kwa peptide, kuthekera kwa transdermal komanso kupezeka kwa bioavailability.