Kapangidwe kazinthu zatsopano

Kudziphatikiza kwa mamolekyu

- chemistry yobiriwira yobiriwira popanda kusweka ndi kulumikizananso

Mfundo yaikulu ya molecular self-assembly:

1. Monga zimakopa ngati - kuyendetsa zinthu zofanana kuti zisonkhane ndi kukonzana, ndi zinthu zomwe zimayenderana kuti zikopane.

2. Mphamvu yotsika kwambiri—kuyenda kwa zinthu ndi kakhalidwe ka maselo kamakhala kokhazikika. Ndi njira yoti magulu a mamolekyu asanjidwe kukhala zinthu zapamwamba.

Kudzipangira kwa mamolekyulu, kapangidwe ka CP pakati pa mamolekyu kumatha kusintha kwambiri zochitika zachilengedwe:

1. Molekyu iliyonse imakhala ndi mawonekedwe ake apadera komanso magwiridwe antchito, ndipo ndizovuta kukwaniritsa ma synergy ndi chithandizo cholondola potengera kusakanikirana kwaufulu pamlingo wopangidwira.

2. Pali mamolekyu ambiri omwe ali ndi zochitika zabwino kwambiri zamoyo zomwe zachepetsa kwambiri kuyamwa ndi kugwiritsa ntchito kwawo chifukwa cha makhalidwe awo oipa.

3. Zomwe zimagwiritsidwa ntchito pamankhwala achi China ndizopadera kwambiri za "mfumu, nduna ndi othandizira", m'malo mokhala movutikira kwambiri.

Supramolecular structure modified and optimization process process model:

1. Kuwunika kwapamwamba kothandizidwa ndi makompyuta kuti awonedwe mwamsanga zotsatila zoyenera kuchokera ku Cambridge Crystal Data Center.

2. Gwiritsani ntchito chiphunzitso cha kachulukidwe ka ntchito kuti muphunzire mawonekedwe a supramolecular ndi katundu wamagulu omwe amatsimikiziridwa ndi mphamvu za intermolecular, ndikuwonetsetsa kuti ndi mtundu wanji wa supramolecular womwe umapangidwira.

3. Pofufuza momwe zinthu zilili komanso zovuta, mawonekedwe a supramolecular adakonzedwa bwino.

4. Kuwerengera zamitundu yosiyanasiyana ya ma supramolecules, kuphatikiza magetsi, kuwala ndi thermodynamic.

5. Mawerengedwe a spectral katundu monga molecular sipekitiramu ndi sipekitiramu mphamvu.

6.Kupyolera mu teknoloji ya docking ya ma molekyulu, malo ochitirana pakati pa zinthu zopangira supramolecular ndi mapuloteni omwe amawunikira amanenedweratu, ndipo njira yolumikizirana pakati pa mamolekyu ikufotokozedwa mozama.

Supramolecular eutectic / Ionic salt technology

Zaukadaulo: choyambirira chamakampani, kuyang'ana zida zabwino kwambiri za CP zomwe zimagwira ntchito polimbitsa eutectic

Ubwino: kuchepetsa kukwiya, kuwonjezera kusungunuka, kukonza magwiridwe antchito, kulimbikitsa permeability, kusintha bata

Zitsanzo za zosakaniza: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK

Zosakaniza zachilengedwe zomwe zimatengedwa pamndandanda wazopangira zodzikongoletsera, pambuyo poyesa kutsimikizira monga quantum chemical simulation, high-throughput screening, Gaussian optimization, KingDraw, MestReNova, FTIR, ndi NMR, zinthu zomwe zapezedwa zili ndi mawonekedwe abwino a kristalo wa mbali zitatu, kukhazikika kwabwino, Kuyera Kwambiri, zosadetsedwa zochepa. Ikhoza kuthetsa bwino zowawa za ntchito zosakaniza mu chakudya, mankhwala ndi zodzoladzola, ndikusintha bioavailability ndi chitetezo cha zosakaniza zinchito.

Ukadaulo wa Supramolecular Extraction Technology

Echnical features: Choyamba chamakampani, kuphatikiza ukadaulo wosindikiza wa ma molekyulu ndi zosungunulira zachilengedwe za supramolecular, kutulutsa koyenera kwa zosakaniza zomwe zimagwira ntchito muzomera.

Ubwino: M'zigawo zomwe zikuyembekezeredwa, kuchuluka kwa m'zigawo kumachulukitsidwa ndi kasanu poyerekeza ndi kutulutsa mowa, ndipo kuchotsa madzi kumawonjezeka ndi nthawi 20; palibe kupatukana, kuchepetsa mtengo, Zopangira zolimbikitsa kulowa Zitsanzo: azitona (oleuropein, hydroxytyrosol), rhodiola, mankhwala Phyloporus, white water lily, micrococcus

Natural deep eutectic solvent (NaDES): Anapezedwa koyamba ndi asayansi pofufuza za metabolomics ya zomera. Pazigawo zina zakukula kwa zomera (kumera, cryopreservation), maselo amadzipangira okha madzi owoneka bwino osadalira madzi ndi lipids, ofanana ndi osakaniza a eutectics.

Kutengera ukadaulo wamakono wolekanitsa wobiriwira, ukadaulo wa nembanemba wophatikizika, wophatikizidwa ndi ukadaulo wa ultrasonic / microwave wowonjezera kutentha kuti akwaniritse kutentha pang'ono, cholinga, high ciency, apamwamba kwambiri komanso obiriwira m'zigawo zogwira ntchito. Zosungunulira za supramolecular zosungunulira zimakhala ndi magwiridwe antchito komanso kusungunuka kwazinthu zomwe zimagwira ntchito, komanso kutulutsa kwachangu kumatha kuonjezedwa nthawi 20.

Supramolecular synergistic malowedwe luso

Zaukadaulo: Choyamba chamakampani, kudzera mu supramolecular zosungunulira synergistically kulimbikitsa kulowa kwa macromolecules/madzi sungunuka/zovuta kuyamwa zosakaniza.

Ubwino waukadaulo: kukhazikika kwabwino, kupititsa patsogolo kosawononga komanso kothandiza kolowera, kuphatikizika kwa synergistic, kuwongolera mayendedwe mu dermis, komanso bioavailability yowonjezereka ndi nthawi 5-7 Zosakaniza zitsanzo: collagen, Bosein, peptide yamkuwa ya buluu, hexapeptide, peptide yamagulu, β-glucan.

Popeza kulemera kwa molekyulu ya peptide ikadali yayikulu poyerekeza ndi zinthu zina zogwira ntchito, kulowa kwa khungu kumakhala kochepa. Njira zina zopititsira patsogolo zolowera zimafunika kuti peptide ilowe m'malo olowera, kuti akwaniritse kukhazikika kwapang'onopang'ono komanso kuchita bwino kwambiri, komanso kukhala ndi mphamvu yoletsa kukalamba.

Poyankha zowawa zamakampani zomwe sizimalowa bwino, kuchuluka kwa hydrophilicity komanso kutsika kwa bioavailability wa ma macromolecules achikhalidwe, JUNAS Time Particle product synthesis kudzera mu chemistry ya quantum imathandizidwa, imatha kufikira epidermis ndi dermis ya khungu kudzera munjira zama cell, intercellular ndi follicular thukuta. Popanda kuwononga khungu.The bioavailability wa mankhwala akuchulukirachulukira 5 nthawi, kuphatikizapo oposa 45% mu dermis, popanda kuwononga khungu structure.The malowedwe olowa ndi kukhala nthawi zakwaniritsidwa pitapita patsogolo.Ichi ndi choyamba cha mtundu wake mu makampani.

Ukadaulo wa Supramolecular biocatalysis

Bioenzyme motsogozedwa ndi catalysis: zosungunulira za supramolecular zimagwiritsidwa ntchito ngati gawo laling'ono kuti lipititse patsogolo ntchito ya ma enzyme, kupititsa patsogolo kusankha kwachiral, ndikukhala oyera kwambiri.

Engineering fennel wobiriwira nayonso mphamvu: sankhani zomera khalidwe, kuonjezera zili zosakaniza yogwira, anhydrous chilinganizo, kusintha lachangu wonse.

Tekinoloje yosinthira micellar fermentation: kuwunika mawonekedwe, kupesa mafuta amasamba, zochulukirapo, kuwongolera kamvekedwe ka khungu ndikuwonjezera kuyamwa.

Kutengera ukadaulo wophatikizanso ma jini, ukadaulo wa gawo limodzi la gene cloning komanso ukadaulo wothandizira kwambiri wa bioenzyme catalytic, mabakiteriya opangidwa ndi majini amagwiritsidwa ntchito ngati zonyamulira kuti azindikire kupanga kwakukulu kwa zinthu zomwe zimagwira ntchito:

Pansi pa supramolecular zosungunulira dongosolo, enzyme imasonyeza ntchito zapamwamba, kusankha ndi kukhazikika, kugwiritsidwa ntchito kwakukulu kwa zopangira zopangira gawo lapansi, kuipitsidwa kochepa pakupanga, mikhalidwe yofatsa, chitetezo chapamwamba komanso kupanga.

Tekinoloje yosinthira micelle fermentation:

Mafuta osankhidwa achilengedwe okhala ndi mawonekedwe aku China lP amapangidwa mwachisawawa kuti apange ma surfactants mothandizidwa ndi ma bacteria.lt amasonkhanitsidwa ngati chonyamulira cha anti-micellar mtolo kuti azindikire kukulunga kwa anti-micellar mtolo wa zosakaniza zosungunuka m'madzi kuti akwaniritse zochitika zogwiritsa ntchito bwino, zokumana nazo zapakhungu, komanso luso, magwiridwe antchito komanso ofunikira.

Supramolecular microencapsulation teknoloji

Mawonekedwe aukadaulo: liposome encapsulation, kutulutsidwa kwachindunji kwa ma cell a dermal, kutulutsa komwe kumapangidwa ndi tsitsi, komanso kutulutsa koyankha kwa zinthu zotupa.

Ubwino: Nanoization, kuperekera molondola, kumasulidwa kwanthawi yayitali, kuchepetsa kukwiya, kuwongolera bata, komanso kulimbikitsa permeability.

Zitsanzo za zosakaniza: astaxanthin, glabridin, vitamini A, blue copper peptide, biotin, ceramide, zomera zofunika mafuta

Ukadaulo wa Supramolecular microencapsulation umachokera ku liposome, emulsion yamafuta, ukadaulo wa ionic liquid stabilization, ukadaulo wa dermal cell targeted release, teknoloji yotulutsa tsitsi, komanso teknoloji yotulutsa yotupa yotulutsa. Ili ndi mayamwidwe abwino kwambiri a transdermal, nthawi yokhala ndi nthawi yayitali komanso kukhazikika kwapakhungu komwe mukufuna. Ilinso ndi ntchito zotsika mtengo komanso zogwira mtima kwambiri pankhani ya zodzoladzola, zakudya zogwira ntchito komanso zamankhwala.

Peptide hierarchical self-assembly teknoloji

Zaukadaulo: kuwongolera koyamba kwamakampani, komwe kumayang'aniridwa pamapangidwe amitundu ingapo ya unyolo wa amino acid ndi ma polypeptides, ma peptide afupi odziphatikiza okha, ma polypeptides apamwamba kwambiri.

Upangiri waukadaulo: Konzani amphiphilicity, onjezerani bata ndi kukana kutentha, kuchepetsa kawopsedwe ndi kupsinjika kwa chitetezo chamthupi, kulimbikitsa kuyamwa, ndi synergize.

Zitsanzo za zosakaniza: supramolecular carnosine, yisiti mapuloteni peptide

Kudziphatikiza kwa mapuloteni ndi ma peptide sikungopezeka paliponse m'machitidwe amoyo, komanso chinthu chabwino kwambiri chamkati mwa thupi la munthu, komanso njira imodzi yopangira zida za nano-biological. Njira yodzipangira ma peptide ndi njira yolumikizirana, ndipo "polar amino acid zipper structure" ndi mtundu watsopano wamapangidwe apamwamba kwambiri, omwe amathandizira kuti ma peptides apangidwe kuti apange magulu olamulidwa.

Kuwongolera kowongolera kukula kwa ma peptide amfupi kumatha kutheka posintha hydrophobicity ndi nthambi zam'mbali za zotsalira za hydrophobic.

Zotengera Shinehigh Innovation wapadera ProteinDataBank (PDB) Nawonso achichepere, kuphatikiza ndi mwadongosolo experimental kuonerera, mphamvu maselo ndi quantum chemistry mawerengedwe kusanthula kapangidwe ka mamolekyu a peptide, ndiyeno kuyanjanitsa ndi mkulu-kudutsa kudzikonda msonkhano mamolekyu. potero kukulitsa luso la molekyulu yodzisonkhanitsa yokha. Peptide yodziphatikiza yokha imakhala ndi amphiphilicity ndi symmetry yabwino kwambiri, yomwe imathandizira kwambiri kukhazikika kwa peptide, kuthekera kwa transdermal ndi bioavailability.