ActiTide™ Bouncera ikuyimira kupita patsogolo kwakukulu mu zosakaniza zodzikongoletsera zochokera ku peptide, zomwe zimapereka njira yodziwika bwino yolimbana ndi ukalamba yopangidwa kuti ithetse zofooka zakale za bioavailability ya peptide. Ngakhale ma peptide amadziwika ndi mphamvu zawo zolumikizirana ndi zamoyo, kugwiritsa ntchito kwawo nthawi zambiri kumakhala koletsedwa ndi hydrophilicity yayikulu komanso kukula kwakukulu kwa mamolekyulu, zomwe zimalepheretsa kuthekera kwawo kulowa mu corneum yolemera mafuta pakhungu. ActiTide™ Bouncera imathetsa mavutowa pophatikiza triple-peptide complex yogwirizana ndi ukadaulo wopereka zinthu zatsopano.
Kugonjetsa Zopinga Zotumizira ndi Ukadaulo wa Supramolecular
Ma peptide achikhalidwe nthawi zambiri amakhala ndi vuto losayamwa bwino kwa transdermal, zomwe zimapangitsa kuti zosakaniza zogwira ntchito zikhalebe pakhungu popanda kufika pa zigawo za khungu zomwe mukufuna. ActiTide™ Bouncera imathetsa vutoli pogwiritsa ntchito Supramolecular Synergistic Penetration Technology, yokhala ndi DES-TG supramolecular ionic liquids.
Njira yatsopanoyi imapanga njira yolumikizirana yoperekera ma peptides—Palmitoyl Tripeptide-5, Hexapeptide-9, ndi Hexapeptide-11—amakonzedwa kukhala supramolecular complex. Ukadaulo uwu umasinthasintha kulowa kwa chotchinga cha khungu mwanjira yolamulidwa komanso "yogwirizana ndi kapangidwe kake", kuonetsetsa kuti zinthu zomwe zimagwira ntchito zimayendetsedwa bwino mu epidermis yakuya ndi dermis popanda kuwononga umphumphu wachilengedwe wa khungu.
Kulowa Kotsimikizika ndi Kupezeka kwa Bioavailability
Kupambana kwaukadaulo kwa ActiTide™ Bouncera kumatsimikiziridwa ndi maphunziro okhwima okhudza kulowa kwa khungu mu vitro. Pogwiritsa ntchito ukadaulo wapamwamba wa fluorescence tracer, mphamvu zolowera za ma peptides mkati mwa complex zidayesedwa. Kafukufukuyu adawonetsa kuti ActiTide™ Bouncera imapeza mphamvu yolowera yomwe ndi nthawi 3 mpaka 5 kuposa gulu lolamulira la peptide iliyonse. Kujambula kwa fluorescence kunatsimikizira kuyang'ana kwambiri khungu, kuonetsetsa kuti zosakaniza zogwira ntchito za biopeptide zimafika ku fibroblasts ndi Dermal-Epidermal Junction (DEJ) komwe zimatha kuchita bwino kwambiri.
Kugwira Ntchito Kwambiri ndi Kumanganso Malungo
Kupatula kuperekedwa kwake kwapamwamba, ActiTide™ Bouncera ikuwonetsa mphamvu yayikulu ya zamoyo m'njira zosiyanasiyana zokalamba m'maphunziro oyesera:
Chithandizo cha Kapangidwe ka DEJ: Chimawonjezera kwambiri mawonekedwe a majini a Collagen IV ndi VII, mapuloteni ofunikira kwambiri polimbitsa Dermal-Epidermal Junction ndikubwezeretsa maziko a khungu.
Kupanga Kolajeni: Mu mayeso ogwira ntchito, kuchuluka kwa 0.15% kokha kunalimbikitsa kupanga Kolajeni ya Mtundu I ndi 332.32%, kusonyeza mphamvu yamphamvu yolimbitsa khungu ndikuchepetsa kuya kwa makwinya.
Kuletsa kuwonongeka kwa kolajeni ndi kutayika kwa kolajeni: Kumapereka chitetezo champhamvu poletsa MMP-1 (enzyme yomwe imayambitsa kuwonongeka kwa kolajeni). Pa kuchuluka kwa 0.10%, milingo ya MMP-1 inachepetsedwa ndi 94.66%, zomwe zinali zabwino kuposa Vitamini C poyerekeza ndi ena.
Katundu wa Fizikiki ndi Ntchito
Malinga ndi fizikiki, ActiTide™ Bouncera ndi madzi opepuka kapena opanda mtundu, opangidwa kuti akhale olimba komanso osavuta kugwiritsa ntchito. Amagwirizana kwambiri ndi zinthu zosiyanasiyana zosamalira khungu, kuphatikizapo ma serum apamwamba, mafuta olimbikitsa, ndi masks obwezeretsa. Mlingo woyenera wa 0.2–5.0% umalola kuti ugwiritsidwe ntchito mosiyanasiyana m'njira zosiyanasiyana zochepetsera makwinya komanso kukonzanso khungu.
Mwachidule, ActiTide™ Bouncera ikuwonetsa kusintha kwaukadaulo kuchokera ku kugwiritsa ntchito peptide wamba kupita ku kuperekedwa kwapamwamba kwa biotechnology. Mwa kuphatikiza kulondola kwa triple-peptide complex ndi mphamvu ya Supramolecular Synergistic Penetration, imapereka yankho loyera kwambiri komanso logwira ntchito bwino kwa mbadwo wotsatira wa chisamaliro cha khungu chaukadaulo. Chitetezo chake chowonetsedwa, kuthekera kwake kolowera mozama (kufikira kulowera kokhazikika ka 3-5 kuposa momwe zimakhalira ndi zowongolera zokhazikika), komanso kugwira ntchito bwino kwambiri kumayiyika ngati chophatikizira chanzeru cha mitundu yodzikongoletsera yapadziko lonse lapansi yomwe ikufuna zotsatira zotsimikizika mwasayansi.
Nthawi yotumizira: Januwale-07-2026