RJMPDRN®REC ikuyimira kupita patsogolo kwakukulu mu zosakaniza zodzikongoletsera zochokera ku nucleic acid, zomwe zimapangitsa kuti PDRN ya nsomba yopangidwanso ipangidwe kudzera mu biotechnology. PDRN yachikhalidwe imachokera makamaka ku nsomba ya nsomba, njira yomwe imayendetsedwa ndi mtengo wokwera, kusiyana kwa batch-to-batch, komanso kuyera kochepa. Kuphatikiza apo, kudalira zachilengedwe kumabweretsa nkhawa zosamalira chilengedwe ndikuchepetsa kukula kwa zinthu kuti zikwaniritse kufunikira kwa msika komwe kukukula.
RJMPDRN®REC ikulimbana ndi mavutowa pogwiritsa ntchito mitundu ya mabakiteriya yopangidwa mwaluso kuti ibwerezenso zidutswa za PDRN zomwe zikufunidwa, zomwe zimathandiza kuti pakhale kupanga kolamulidwa komanso kusunga khalidwe loberekana komanso kuchepetsa kuwononga chilengedwe.
Njira yogwirizanitsa iyi imalola kapangidwe kolondola ka magawo ogwira ntchito, zomwe zimapangitsa kuti zinthu za nucleic acid zipangidwe kuti zigwirizane ndi zotsatira zake za bioactive. Kulemera kwa mamolekyulu ndi kapangidwe ka zidutswazo zimayendetsedwa mosamala, zomwe zimapangitsa kuti zikhale zofanana komanso kuti khungu lilowe. Monga chosakaniza chopanda nyama, RJMPDRN®REC ikugwirizana ndi miyezo yapadziko lonse lapansi, kukulitsa kuvomerezeka kwa msika m'madera ovuta. Njira yopangirayi imatsatira miyezo yokhwima yaubwino, pogwiritsa ntchito njira zoyeretsera ndi kuwiritsa zomwe zimapereka mtundu wokhazikika, chiyero chapamwamba, komanso kupezeka kodalirika—kuthana ndi mtengo, unyolo woperekera, komanso mavuto azachilengedwe okhudzana ndi kuchotsa zinthu mwachizolowezi.
Kapangidwe ka thupi, RJMPDRN®REC ndi ufa woyera, wosungunuka m'madzi wopangidwa ndi DNA yokhala ndi RNA yaying'ono, yochokera ku ma PDRN a nsomba ya salmon, ndipo ili ndi pH ya 5.0–9.0. Imayikidwa m'gulu la zodzoladzola zoyenera kugwiritsidwa ntchito mu emulsions zapamwamba, mafuta, ma patches a maso, masks, ndi zina zosamalira khungu zapamwamba. Kafukufuku wa mu vitro wasonyeza kuti ndi wotetezeka komanso wogwira ntchito bwino pamlingo wa 100–200 μg/mL, kuthandizira kuchulukana kwa maselo ndi ntchito yolimbana ndi kutupa popanda cytotoxicity.
Maphunziro okhudza kugwira ntchito bwino kwa RJMPDRN akuwonetsanso kuti RJMPDRN imagwira ntchito bwino kwambiri m'thupi.®REC. Imathandizira kwambiri kusamuka kwa fibroblast, zomwe zimapangitsa kuti kuchulukana kwa maselo kuchuluke ndi 131% pakatha maola 41 poyerekeza ndi olamulira. Ponena za kapangidwe ka collagen, RJMPDRN®REC imalimbikitsa collagen ya mtundu woyamba wa anthu ndi nthawi 1.5 ndi collagen ya mtundu wachitatu ndi nthawi 1.1 poyerekeza ndi zowongolera, zomwe zimagwira ntchito bwino kuposa PDRN yochokera ku salmon. Kuphatikiza apo, imaletsa kwambiri zotupa monga TNF-α ndi IL-6. Ikaphatikizidwa ndi sodium hyaluronate, , RJMPDRN®REC ikuwonetsa zotsatira zogwirizana, kuonjezera kusamuka kwa maselo, zomwe zikusonyeza kuthekera kwakukulu kwa njira zogwirira ntchito limodzi pakusamalira khungu lobwezeretsa komanso loletsa kukalamba.
Mwachidule, RJMPDRN®REC ikuwonetsa kusintha kwa ukadaulo kuchokera ku kuchotsa zinthu zakale kupita ku kupanga zinthu zamoyo, zomwe zimapereka njira ina yoberekera, yoyera kwambiri, komanso yokhazikika yopangira zinthu zapamwamba zosamalira khungu. Kuwonetsa kwake kuti imagwira ntchito bwino, chitetezo chake, komanso kukula kwake zimaiyika ngati chida chofunikira kwambiri pa zinthu zodzikongoletsera zomwe zimayang'ana kwambiri kukalamba, kukonza khungu, komanso thanzi la khungu lonse, mogwirizana ndi kufunikira kwa zosakaniza zodzikongoletsera zokhazikika komanso zovomerezeka mwasayansi.
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Nthawi yotumizira: Ogasiti-28-2025